Quantitative Proteomic Analysis of Non-Tobacco Associated Oral Squamous Cell Carcinoma Reveals Deregulation of Cytoskeletal and Apoptotic Proteins.

ABSTRACT:

Background

The exact etiology of non-tobacco associated oral squamous cell carcinoma (NT-OSCC) is still unknown. The lack of established biomarkers for oral NT-OSCC has resulted in less effective management and poor prognosis. Here, we report for the first time a panel of potential markers identified from the quantitative proteomic analysis of NT-OSCC using two-dimensional gel-electrophoresis (2D-GE) using matrix-assisted laser desorption/ionization - time of flight (MALDI-TOF) coupled with mass spectrometry (MS) and further analysis using protein analysis through evolutionary relationships (PANTHER) database.

Objective

To quantitatively analyze the proteomic profile of non-tobacco associated oral squamous cell carcinoma.

Methods

Twenty fresh tissue samples were colle

SUBMITTER: T A S 

PROVIDER: S-EPMC9971460 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature