Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation.

ABSTRACT:

Background

Pain plays an important role in chronic ankle instability (CAI), and prolonged pain may be associated with ankle dysfunction and abnormal neuroplasticity.

Purpose

To investigate the differences in resting-state functional connectivity among the pain-related brain regions and the ankle motor-related brain regions between healthy controls and patients with CAI, and explore the relationship between patients' motor function and pain.

Study design

A cross-database, cross-sectional study.

Methods

This study included a UK Biobank dataset of 28 patients with ankle pain and 109 healthy controls and a validation dataset of 15 patients with CAI and 15 healthy controls. All participants underwent resting-state functional magnetic resonance imaging scanning, and

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9971622 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature