Association between bilirubin levels with incidence and prognosis of stroke: A meta-analysis.

ABSTRACT:

Objective

Bilirubin has anti-inflammatory, antioxidant, and neuroprotective properties, but the association between bilirubin and stroke remains contentious. A meta-analysis of extensive observational studies on the relationship was conducted.

Methods

Studies published before August 2022 were searched in PubMed, EMBASE, and Cochrane Library. Cohort, cross-sectional and case-control studies that examined the association between circulating bilirubin and stroke were included. The primary outcome included the incidence of stroke and bilirubin quantitative expression level between stroke and control, and the secondary outcome was stroke severity. All pooled outcome measures were determined using random-effects models. The meta-analysis, subgroup analysis, and sensitivity analysi

SUBMITTER: Zhao K 

PROVIDER: S-EPMC9971723 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature