Iron status and obesity-related traits: A two-sample bidirectional Mendelian randomization study

ABSTRACT:

Background

The association between iron status and obesity-related traits is well established by observational studies, but the causality is uncertain. In this study, we performed a two-sample bidirectional Mendelian randomization analysis to investigate the causal link between iron status and obesity-related traits.

Methods

The genetic instruments strongly associated with body mass index (BMI), waist-hip ratio (WHR), serum ferritin, serum iron, transferrin saturation (TSAT), and total iron-binding capacity (TIBC) were obtained through a series of screening processes from summary data of genome-wide association studies (GWAS) of European individuals. We used numerous MR analytical methods, such as inverse-variance weighting (IVW), MR-Egger, weighted median, and maximum li

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC9971727 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature