Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock.

ABSTRACT: Timed daily access to a running-wheel (scheduled voluntary exercise; SVE) synchronizes rodent circadian rhythms and promotes stable, 24h rhythms in animals with genetically targeted impairment of neuropeptide signaling (Vipr2 ^-/- mice). Here we used RNA-seq and/or qRT-PCR to assess how this neuropeptide signaling impairment as well as SVE shapes molecular programs in the brain clock (suprachiasmatic nuclei; SCN) and peripheral tissues (liver and lung). Compared to Vipr2 ^+/+ animals, the SCN transcriptome of Vipr2 ^-/- mice showed extensive dysregulation which included core clock components, transcription factors, and neurochemicals. Furthermore, although SVE stabilized behavioral rhythms in these animals, the SCN tra

SUBMITTER: Hitrec T 

PROVIDER: S-EPMC9971895 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature