Palladin promotes cancer stem cell-like properties in lung cancer by activating Wnt/Β-Catenin signaling.

ABSTRACT:

Background

Cancer stem cells (CSCs) are responsible for drug resistance, cancer relapse, and metastasis. Here, we report the first analysis of Palladin expression and its impacts on stem cell-like properties in lung cancer.

Methods

Tissue microarrays were used to investigate Palladin expression and its association with prognosis. Immunofluorescence (IF), flow fluorescence assay, and Western blot were performed to detect Palladin expression in 6 NSCLC cell lines. Cell phenotypes and drug resistance were evaluated. Xenograft models were constructed to confirm the role of Palladin in vivo.

Results

By using the tissue microarrays, Palladin was identified to be highly expressed in the cytoplasm, specifically in the cytomembrane of NSCLC, and its high expression is associat

SUBMITTER: Shu X 

PROVIDER: S-EPMC9972019 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature