Adenosine deaminase-based measurement in the differential diagnosis of pleural effusion: a multicenter retrospective study.

ABSTRACT:

Introduction

The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.

Methods

266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based measurement for tuberculous pleural effusion (TPE), malignant pleural effusion (MPE), and parapneumonic effusion (PPE) was examined by receiver operating characteristic (ROC) curve analysis.

Results

An area under the ROC curve (

SUBMITTER: Gao L 

PROVIDER: S-EPMC9972043 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature