Dirty necrosis in renal cell carcinoma is associated with NETosis and systemic inflammation.

ABSTRACT:

Aim

Dirty necrosis (DN) in renal cell carcinoma (RCC) is morphologically characterized by abundant neutrophil infiltration and has significant potential as an unfavorable prognostic indicator. This study aimed to analyze the pathological and biological features of DN.

Materials and methods

A total of 81 RCC tumors, including 33 cases of DN and 48 cases of tumor necrosis without DN features (ghost necrosis [GN]), were enrolled in this study. We compared the number of neutrophils; the activation of cell death pathways, including ferroptosis, NETosis, and apoptosis; the rate of epithelial-mesenchymal transition (EMT); and proliferation status using immunohistochemistry. We further assessed the effect of the necrosis type on systemic inflammation.

Results

DN tumors had a

SUBMITTER: Kuroe T 

PROVIDER: S-EPMC9972113 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature