Circulating cytokines allow for identification of malignant intraductal papillary mucinous neoplasms of the pancreas.

ABSTRACT:

Background

Intraductal papillary mucinous neoplasms (IPMNs) are the precursor lesions of pancreatic cancers, requiring active surgical intervention during cancer development. However, the current criteria for predicting malignant IPMNs remain challenging and limited. Hence, this study aimed to assess the discriminatory performance of circulating cytokines, including TNF-α, IL-2R, IL-6, and IL-8, then build a novel predictive model to improve the diagnostic accuracy.

Method

A total of 131 retrospective (from March 2016 to December 2019) and 53 prospective (from March 2020 to January 2021) patients who were histologically confirmed as IPMNs were consecutively collected and analyzed.

Result

The circulating levels of TNF-α, IL-2R, IL-6, and IL-8 were significantly elevate

SUBMITTER: Pu N 

PROVIDER: S-EPMC9972143 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature