A pyroptosis-related signature predicts prognosis and indicates immune microenvironment infiltration in glioma.

ABSTRACT:

Background

Glioma, the most common malignant brain tumor, leads to high recurrence rates and disabilities in patients. Pyroptosis is an inflammasomes-induced programmed cell death in response to infection or chemotherapy. However, the role of pyroptosis in glioma has not yet been elucidated.

Methods

RNA-seq data and clinical information of 660 gliomas and 847 samples were downloaded from the TCGA and CGGA, respectively. Then, data of 104 normal brain tissues was retrieved from the GTEx for differential expression analysis. Twelve pairs of peritumoral tissue and glioma samples were used for validation. Gene alteration status of differentially expressed pyroptosis-related regulators in gliomas was detected in cBioPortal algorithm. Consensus clustering was employed to classify

SUBMITTER: Chen J 

PROVIDER: S-EPMC9972150 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature