Metabolic pathways enriched according to ERG status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer.

ABSTRACT:

Background

The role of ERG-status molecular subtyping in prognosis of prostate cancer (PCa) is still under debate. In this study, we identified differentially expressed genes (DEGs) according to ERG-status to explore their enriched pathways and implications in prognosis in Hispanic/Latino PCa patients.

Methods

RNA from 78 Hispanic PCa tissues from radical prostatectomies (RP) were used for RNA-sequencing. ERG_high /ERG_low tumor groups were determined based on the 1.5-fold change median expression in non-tumor samples. DEGs with a False Discovery Rate (FDR) < 0.01 and a fold change >2 were identified between ERG_high and ERG_low tumors and submitted to enrichment analysis in MetaCore. Survival and association analyses were performed to

SUBMITTER: Acosta-Vega NL 

PROVIDER: S-EPMC9972164 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature