Dataset Information
Fingerprick blood samples to measure serum natalizumab concentrations.
Ontology highlight
ABSTRACT: Background
Natalizumab via subcutaneous administration was recently approved for patients with multiple sclerosis.Objective
In light of personalized extended dosing, in which treatment intervals are prolonged to a concentration cut-off, it would be preferable to measure natalizumab drug concentrations in capillary blood.Methods
In this cross-sectional study in patients treated with intravenous (IV) natalizumab, capillary blood samples by fingerprick and venous blood samples were collected in 30 participants prior to IV administration of natalizumab.Results
Natalizumab concentrations were similar with a mean bias of -0.36 μg/mL (95% CI: 1.3 to -2 μg/mL).Conclusions
This study shows that physicians can monitor natalizumab drug concentrations by a fingerprick, which could be used for personalized extended dosing.
SUBMITTER: Toorop AA
PROVIDER: S-EPMC9972227 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Fingerprick blood samples to measure serum natalizumab concentrations.
Multiple sclerosis (Houndmills, Basingstoke, England) 20221130 3
<h4>Background</h4>Natalizumab via subcutaneous administration was recently approved for patients with multiple sclerosis.<h4>Objective</h4>In light of personalized extended dosing, in which treatment intervals are prolonged to a concentration cut-off, it would be preferable to measure natalizumab drug concentrations in capillary blood.<h4>Methods</h4>In this cross-sectional study in patients treated with intravenous (IV) natalizumab, capillary blood samples by fingerprick and venous blood sampl ...[more]