Relationship between paramagnetic rim lesions and slowly expanding lesions in multiple sclerosis.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) markers for chronic active lesions in MS include slowly expanding lesions (SELs) and paramagnetic rim lesions (PRLs).

Objectives

To identify the relationship between SELs and PRLs in MS, and their association with disability.

Methods

61 people with MS (pwMS) followed retrospectively with MRI including baseline susceptibility-weighted imaging, and longitudinal T1 and T2-weighted scans. SELs were computed using deformation field maps; PRLs were visually identified. Mixed-effects models assessed differences in Expanded Disability Status Scale (EDSS) score changes between the group defined by the presence of SELs and or PRLs.

Results

The median follow-up time was 3.2 years. At baseline, out of 1492 lesions, 616 were class

SUBMITTER: Calvi A 

PROVIDER: S-EPMC9972234 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature