Association of HTR3B gene polymorphisms with depression and its executive dysfunction: a case-control study.

ABSTRACT:

Background

Previous studies have shown that depression was associated with HTR3B gene. The aim of this study was to investigate the relationship between polymorphisms of the HTR3B gene and depression and its executive dysfunction in Chinese Han population.

Methods

A total of 229 patients with depressive disorder and 202 healthy controls were enrolled. Six Single nucleotide polymorphism sites (SNPs) including rs10789970, rs4938056, rs12421126, rs1176744, rs2276305 and rs12795805 were genotyped by Snapshot. Clinical features were collected using a general demographic questionnaire. The 24-item Hamilton Depression Scale (HAMD) was used to assess the symptoms' severity of the patients. The patients' executive function was assessed using a series of cognitive tests including Maze

SUBMITTER: Wang L 

PROVIDER: S-EPMC9972617 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature