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CorrectKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes.

ABSTRACT: Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×-11.9×) using samples with known family relations and known/unknown population structure. Based on our results, correctKin allows for the reliable identification of relatedness up to the 4th degree from variable/low-coverage ancient or badly degraded forensic whole genome sequencing data.

SUBMITTER: Nyerki E

PROVIDER: S-EPMC9972692 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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correctKin: an optimized method to infer relatedness up to the 4th degree from low-coverage ancient human genomes.

Nyerki Emil E Kalmár Tibor T Schütz Oszkár O Lima Rui M RM Neparáczki Endre E Török Tibor T Maróti Zoltán Z

Genome biology 20230228 1

Kinship analysis from very low-coverage ancient sequences has been possible up to the second degree with large uncertainties. We propose a new, accurate, and fast method, correctKin, to estimate the kinship coefficient and the confidence interval using low-coverage ancient data. We perform simulations and also validate correctKin on experimental modern and ancient data with widely different genome coverages (0.12×-11.9×) using samples with known family relations and known/unknown population stru ...[more]

PMID: 36855115

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