ATP2B4 regulatory genetic variants are associated with mild malaria.

ABSTRACT:

Background

Genome-wide association studies have identified ATP2B4 as a severe malaria resistance gene. Recently, 8 potential causal regulatory variants have been shown to be associated with severe malaria.

Methods

Genotyping of rs10900585, rs11240734, rs1541252, rs1541253, rs1541254, rs1541255, rs10751450, rs10751451 and rs10751452 was performed in 154 unrelated individuals (79 controls and 75 mild malaria patients). rs10751450, rs10751451 and rs10751452 were genotyped by Taqman assays, whereas the fragment of the ATP2B4 gene containing the remaining SNPs was sequenced. Logistic regression analysis was used to assess the association between the SNPs and mild malaria.

Results

The results showed that mild malaria was associated with rs10900585, rs11240734, rs1541252, rs

SUBMITTER: Thiam A 

PROVIDER: S-EPMC9972758 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature