Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m⁶A/NT5DC3/HKDC1 axis.

ABSTRACT:

Background

Although the relationship between type 2 diabetes (T2D) and the increased risk of colorectal carcinogenesis is widely defined in clinical studies, the therapeutic methods and molecular mechanism of T2D-induced colon cancer and how does hyperglycemia affect the progression is still unknown. Here, we studied the function of lactoferrin (LF) in suppressing the progression of colon cancer in T2D mice, and uncovered the related molecular mechanisms in DNA 5mC and RNA m6A levels.

Methods

We examined the effects of LF (50% iron saturation) on the migration and invasion of colon tumor cells under high concentration of glucose. Then, transcriptomics and DNA methylation profilings of colon tumor cells was co-analyzed to screen out the special gene (NT5DC3), and the expressi

SUBMITTER: Li H 

PROVIDER: S-EPMC9972781 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature