The joint effects of nanoplastics and TBBPA on neurodevelopmental toxicity in Caenorhabditis elegans.

ABSTRACT: Both of nanoplastics (NPs) and Tetrabromobisphenol A (TBBPA) are organic pollutants widely detected in the environment and organisms. The large specific surface area of NPs makes them ideal vectors for carrying various toxicants, such as organic pollutants, metals, or other nanomaterials, posing potential threats to human health. This study used Caenorhabditis elegans (C. elegans) to investigate the neurodevelopmental toxicity induced by combined exposure of TBBPA and polystyrene NPs. Our results showed that combined exposure caused synergistic inhibitory effects on the survival rate, body length/width, and locomotor ability. Furthermore, the overproduction of reactive oxygen species (ROS), lipofuscin accumulation, and dopaminergic neuronal loss suggested that oxidative stres

SUBMITTER: Zhao K 

PROVIDER: S-EPMC9972810 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature