Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort

ABSTRACT: ABSTRACT

Background

Lymphocyte ratios reflect inflammation and have been associated with adverse outcomes in a range of diseases. We sought to determine any association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality in a haemodialysis cohort, including a coronavirus disease 2019 (COVID-19) infection subpopulation.

Methods

A retrospective analysis was performed of adults commencing hospital haemodialysis in the West of Scotland during 2010–21. NLR and PLR were calculated from routine samples around haemodialysis initiation. Kaplan–Meier and Cox proportional hazards analyses were used to assess mortality associations.

Results

In 1720 haemodialysis patients over a median of 21.9 (interquartile range 9.1–42.9) months

SUBMITTER:  

PROVIDER: S-EPMC9972818 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature