Drugs associated with incident fragility fractures in kidney transplant recipients

ABSTRACT: ABSTRACT

Background

The risk of fragility fractures is high in kidney transplant recipients, and steroids are reportedly a major cause. Other drugs known to induce fragility fractures have been studied in the general population but not in kidney transplant recipients. Here, we investigated the association between exposure over time to drugs that can injure bone (namely vitamin K antagonists, insulin, loop diuretics, proton pump inhibitors, opioids, selective serotonin reuptake inhibitors, antiepileptics and benzodiazepines) and incident fractures and changes over time in T-scores in this population.

Methods

A total of 613 consecutive kidney transplant recipients were included between 2006 and 2019. Drug exposures and incident fractures during the study period were compreh

SUBMITTER:  

PROVIDER: S-EPMC9972841 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature