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Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs).

ABSTRACT: An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.

SUBMITTER: Lerch S

PROVIDER: S-EPMC9972882 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs).

Lerch Swantje S Fritsch Stefan S Strassner Thomas T

Beilstein journal of organic chemistry 20230223

An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale. ...[more]

PMID: 36865025

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