Modelling the Gastrointestinal Carriage of Klebsiella pneumoniae Infections.

ABSTRACT: Klebsiella pneumoniae is a leading cause of nosocomial and community acquired infections, making K. pneumoniae the pathogen that is associated with the second largest number of deaths attributed to any antibiotic resistant infection. K. pneumoniae colonizes the nasopharynx and the gastrointestinal tract in an asymptomatic manner without dissemination to other tissues. Importantly, gastrointestinal colonization is a requisite for infection. Our understanding of K. pneumoniae colonization is still based on interrogating mouse models in which animals are pretreated with antibiotics to disturb the colonization resistance imposed by the gut microbiome. In these models, infections disseminate to other tissues. Here, we report a murine model to allow for the study of the gastrointestinal coloniza

SUBMITTER: Calderon-Gonzalez R 

PROVIDER: S-EPMC9972987 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature