cotH Genes Are Necessary for Normal Spore Formation and Virulence in Mucor lusitanicus.

ABSTRACT: Mucormycosis is an invasive fungal infection caused by certain members of the fungal order of Mucorales. The species most frequently identified as the etiological agents of mucormycosis belong to the genera Rhizopus, Lichtheimia, and Mucor. The frequency of systemic mucormycosis has been increasing, mainly because of increasing numbers of susceptible patients. Furthermore, Mucorales display intrinsic resistance to the majority of routinely used antifungal agents (e.g., echinocandins and short-tailed azoles), which limits the number of possible therapeutic options. All the above-mentioned issues urge the improvement of molecular identification methods and the discovery of new antifungal targets and strategies. Spore coat proteins (CotH) constitute a kinase family presen

SUBMITTER: Szebenyi C 

PROVIDER: S-EPMC9973265 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature