Analysis of Pneumocystis Transcription Factor Evolution and Implications for Biology and Lifestyle.

ABSTRACT: Pneumocystis jirovecii kills hundreds of thousands of immunocompromised patients each year. Yet many aspects of the biology of this obligate pathogen remain obscure because it is not possible to culture the fungus in vitro independently of its host. Consequently, our understanding of Pneumocystis pathobiology is heavily reliant upon bioinformatic inferences. We have exploited a powerful combination of genomic and phylogenetic approaches to examine the evolution of transcription factors in Pneumocystis species. We selected protein families (Pfam families) that correspond to transcriptional regulators and used bioinformatic approaches to compare these families in the seven Pneumocystis species that have been sequenced to date with those from other yeasts, other human and plant pathoge

SUBMITTER: Ames R 

PROVIDER: S-EPMC9973273 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature