Helicobacter pylori Chronic Infection Selects for Effective Colonizers of Metaplastic Glands.

ABSTRACT: Chronic gastric infection with Helicobacter pylori can lead to progressive tissue changes that culminate in cancer, but how H. pylori adapts to the changing tissue environment during disease development is not fully understood. In a transgenic mouse gastric metaplasia model, we found that strains from unrelated individuals differed in their ability to infect the stomach, to colonize metaplastic glands, and to alter the expression of the metaplasia-associated protein TFF3. H. pylori isolates from different stages of disease from a single individual had differential ability to colonize healthy and metaplastic gastric glands. Exposure to the metaplastic environment selected for high gastric colonization by one of these strains. Complete genome sequencing revealed a unique alteration in the fr

SUBMITTER: O'Brien VP 

PROVIDER: S-EPMC9973278 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature