Emergence and Potential Extinction of Genetic Lineages of Human Metapneumovirus between 2005 and 2021.

ABSTRACT: Human metapneumovirus (HMPV) is one of the leading causes of respiratory illness (RI), primarily in infants. Worldwide, two genetic lineages (A and B) of HMPV are circulating that are antigenically distinct and can each be further divided into genetic sublineages. Surveillance combined with large-scale whole-genome sequencing studies of HMPV are scarce but would help to identify viral evolutionary dynamics. Here, we analyzed 130 whole HMPV genome sequences obtained from samples collected from individuals hospitalized with RI and partial fusion (n = 144) and attachment (n = 123) protein gene sequences obtained from samples collected from patients with RI visiting general practitioners between 2005 and 2021 in the Netherlands. Phylogenetic analyses demonstrated that HMPV contin

SUBMITTER: Groen K 

PROVIDER: S-EPMC9973309 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature