Validation of T₂ -based oxygen extraction fraction measurement with ¹⁵ O positron emission tomography.

ABSTRACT:

Purpose

To evaluate the accuracy of T₂ -based whole-brain oxygen extraction fraction (OEF) estimation by comparing it with gold standard ¹⁵ O-PET measurements.

Methods

Sixteen healthy adult subjects underwent MRI and ¹⁵ O-PET OEF measurements on the same day. On MRI, whole-brain OEF was quantified by T₂ -relaxation-under-spin-tagging (TRUST) MRI, based on subject-specific hematocrit. The TRUST OEF was compared to the whole-brain averaged OEF produced by ¹⁵ O-PET. Agreement between TRUST and ¹⁵ O-PET whole-brain OEF measurements was examined in terms of intraclass correlation coefficient (ICC) and in absolute OEF values. In a subset of 10 subjects, test-retest reproducibility of whole-brain OEF was also evaluat

SUBMITTER: Jiang D 

PROVIDER: S-EPMC9973312 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature