Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation.

ABSTRACT: Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or "retrotransposons," mobilize through the production of an RNA intermediate that is then reverse transcribed to form complementary DNA (cDNA) molecules capable of genomic reinsertion. While TEs are traditionally silenced to maintain genomic integrity, the recognition of immunostimulatory cues, such as those provided by microorganisms, drastically alters host transcription to induce the differential expression of TEs. Emerging evidence demonstrates that the inducible production of TE cDNA is not an inert phenomenon but instead has been coopted by host immunity to facilitate cross talk between host and constituents of the microbiota by agonizing intrinsic antiviral receptor

SUBMITTER: Dopkins N 

PROVIDER: S-EPMC9973353 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature