Comprehensive Immunoprofiling of High-Risk Oral Proliferative and Localized Leukoplakia.

ABSTRACT: Oral leukoplakia is common and may, in some cases, progress to carcinoma. Proliferative leukoplakia is a progressive, often multifocal subtype with a high rate of malignant transformation compared with the more common localized leukoplakia. We hypothesized that the immune microenvironment and gene expression patterns would be distinct for proliferative leukoplakia compared with localized leukoplakia. We summarize key clinicopathologic features among proliferative leukoplakia and localized leukoplakia and compare cancer-free survival (CFS) between subgroups. We analyze immunologic gene expression profiling in proliferative leukoplakia and localized leukoplakia tissue samples (NanoString PanCancer Immune Oncology Profiling). We integrate immune cell activation and spatial distribution patter

SUBMITTER: Hanna GJ 

PROVIDER: S-EPMC9973379 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature