Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer.

ABSTRACT:

Purpose

Mistletoe extract (ME) is widely used for patients with cancer to support therapy and to improve quality of life (QoL). However, its use is controversial due to suboptimal trials and a lack of data supporting its intravenous administration.

Materials and methods

This phase I trial of intravenous mistletoe (Helixor M) aimed to determine the recommended phase II dosing and to evaluate safety. Patients with solid tumor progressing on at least one line of chemotherapy received escalating doses of Helixor M three times a week. Assessments were also made of tumor marker kinetics and QoL.

Results

Twenty-one patients were recruited. The median follow-up duration was 15.3 weeks. The MTD was 600 mg. Treatment-related adverse events (AE) occurred in 13 patients (61.9%),

SUBMITTER: Paller CJ 

PROVIDER: S-EPMC9973409 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature