Left Ventricular Apical Aneurysm in Fabry Disease: Implications for Clinical Significance and Risk Stratification.

ABSTRACT: Background A previously underrecognized phenotype of left ventricular apical aneurysm (LVAA) has been increasingly identified in Fabry disease. This study explored LVAA's clinical prevalence and its prognostic implications over a long-term follow-up. Methods and Results We retrospectively analyzed 268 consecutive patients with Fabry disease at a tertiary medical center. Patients with increased left ventricular mass index were recognized as having left ventricular hypertrophy (LVH). LVAA was identified using either echocardiography or cardiovascular magnetic resonance imaging. Two patients with ischemic LVAA were excluded. The primary end point was a composite of cardiovascular events, including heart failure hospitalization, sustained ventricular tachycardia, ischemic stroke, and all-cause

SUBMITTER: Chang HC 

PROVIDER: S-EPMC9973567 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature