Immune Dysregulation in Acute SARS-CoV-2 Infection

ABSTRACT:

Introduction:

Neutralizing antibodies have been shown to develop rapidly following SARS-CoV-2 infection, specifically against spike (S) protein, where cytokine release and production is understood to drive the humoral immune response during acute infection. Thus, we evaluated the quantity and function of antibodies across disease severities and analyzed the associated inflammatory and coagulation pathways to identify acute markers that correlate with antibody response following infection.

Methods:

Blood samples were collected from patients at time of diagnostic SARS-CoV-2 PCR testing between March 2020-November 2020. Plasma samples were analyzed using the MesoScale Discovery (MSD) Platform using the COVID-19 Serology Kit and U-Plex 8 analyte multiplex plate to measure ant

SUBMITTER: Grimm L 

PROVIDER: S-EPMC9973727 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature