Clinical course of non-alcoholic fatty liver disease and the implications for clinical trial design.

ABSTRACT:

Background & aims

The predicted risk and timeline to progression to liver-related outcomes in the population with NAFLD are not well-characterized. We aimed to examine the risk and time to progression to cirrhosis, hepatic decompensation and death in a contemporary population over a long follow-up period, to obtain information to guide endpoint selection and sample size calculations for clinical trials on NAFLD-related cirrhosis.

Methods

This is a retrospective study of prospectively collected data in a medical record linkage system, including all adults diagnosed with NAFLD between 1996-2016 by clinical, biochemical and radiological criteria in Olmsted County, Minnesota and followed until 2019. Liver-related outcomes and death were ascertained and validated by individual me

SUBMITTER: Allen AM 

PROVIDER: S-EPMC9974107 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature