Risk stratification for hepatocellular cancer among patients with cirrhosis using a hepatic fat polygenic risk score.

ABSTRACT:

Background

Polygenic risk scores (PRS) hold the promise to refine prognostication in hepatocellular cancer (HCC). The few available HCC PRS include germline risk variants identified among individuals of mostly European ancestry, but data are lacking on the transportability of these PRS in multiethnic U.S patients with cirrhosis from multiple etiologies.

Methods

We used data from 1644 patients with cirrhosis enrolled in two prospective cohort studies in the U.S. Patients were followed until HCC diagnosis, death, liver transplantation, or last study visit through June 30, 2021. The high-risk variants in PNPLA3-MBOAT7-TM6SF2-GCKR were combined in a PRS and we evaluated its association with HCC. Discriminatory accuracy was assessed using the C-statistic.

Results

During 4,

SUBMITTER: Thrift AP 

PROVIDER: S-EPMC9974109 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature