Cocaine administration protects gut mucosa barrier and reduces plasma level of TNF-α.

ABSTRACT:

Background

Cocaine affects not only the central nervous system, but also systemic immunity. The role of cocaine in gut mucosal integrity is not fully understood.

Methods

Here we evaluated the effect of cocaine use on gut endothelial permeability and system inflammation in rats that self-administered cocaine or saline and in humans using immunohistochemistry, qPCR, ELISA, and Transepithelial/transendothelial electrical resistance (TEER).

Results

Cocaine administration maintained intact and undisturbed intestinal mucosal structures, increased tight junction claudin 1 and 2 mRNA expression, and decreased plasma TNF-α levels, compared to the control group, at the end of study in rats. Further, cocaine treatment decreased gut endothelial permeability in a dose-dependent ma

SUBMITTER: Fu X 

PROVIDER: S-EPMC9974179 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature