Intraspecific genetic variation in host vigour, viral load and disease tolerance during Drosophila C virus infection.

ABSTRACT: Genetic variation for resistance and disease tolerance has been described in a range of species. In Drosophila melanogaster, genetic variation in mortality following systemic Drosophila C virus (DCV) infection is driven by large-effect polymorphisms in the restriction factor pastrel (pst). However, it is unclear if pst contributes to disease tolerance. We investigated systemic DCV challenges spanning nine orders of magnitude, in males and females of 10 Drosophila Genetic Reference Panel lines carrying either a susceptible (S) or resistant (R) pst allele. We find among-line variation in fly survival, viral load and disease tolerance measured both as the ability to maintain survival (mortality tolerance) and reproduction (fecundity tolerance). We further un

SUBMITTER: Kutzer MAM 

PROVIDER: S-EPMC9974301 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature