The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis.

ABSTRACT:

Background

Osteoarthritis of the knee is an irreversible disease that causes great pain, and genetic factors play an important role in its occurrence and development. There have been many studies on the correlation between ADAM12 polymorphisms and genetic susceptibility to osteoarthritis, but the results remain inconclusive.

Methods

Papers from PubMed, Web of Science, EMbase, Springer, SCOPUS, Google Scholar and other databases were systematically retrieved with a cut-off of January 2022. All case-control studies on ADAM12 rs3740199, rs1871054, rs1044122, and rs1278279 polymorphisms and osteoarthritis were searched. Fixed or random effects models were used for pooled analysis with OR values and 95% confidence intervals (CI), and publication bias was assessed. In addition, th

SUBMITTER: Yang S 

PROVIDER: S-EPMC9974398 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature