Randomized controlled trials of biomarker targets.

ABSTRACT:

Introduction

Randomized controlled trials are used to estimate the causal effect of a treatment on a health outcome of interest in a patient population. Often the specified treatment in a randomized controlled trial is a medical intervention-such as a drug or procedure-experienced directly by the patient. Sometimes the "treatment" in a randomized controlled trial is a target-such as a goal biomarker measurement-that the patient's physician attempts to reach using available medications or procedures. Large randomized controlled trials of biomarker targets are common in clinical research, and trials have been conducted to compare targets in the management of hypertension, diabetes, anemia, and acute respiratory distress syndrome. However, different randomized controlled trials intend

SUBMITTER: Erlendsdottir M 

PROVIDER: S-EPMC9974557 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature