Association of Kidney Function Measures With Signs of Neurodegeneration and Small Vessel Disease on Brain Magnetic Resonance Imaging: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Rationale & objective

Chronic kidney disease (CKD) is a risk factor for cognitive decline, but evidence is limited on its etiology and morphological manifestation in the brain. We evaluated the association of estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR) with structural brain abnormalities visible on magnetic resonance imaging (MRI). We also assessed whether this association was altered when different filtration markers were used to estimate GFR.

Study design

Cross-sectional study nested in a cohort study.

Setting & participants

1,527 participants in the Atherosclerosis Risk in Communities (ARIC) Study.

Predictors

Log(UACR) and eGFR based on cystatin C, creatinine, cystatin C and creatinine in combination, or β₂

SUBMITTER: Scheppach JB 

PROVIDER: S-EPMC9974563 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature