Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC9974593 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Chen Yuang Y Huang Yixian Y Li Qinzhe Q Luo Zhangyi Z Zhang Ziqian Z Huang Haozhe H Sun Jingjing J Zhang LinXinTian L Sun Runzi R Bain Daniel J DJ Conway James F JF Lu Binfeng B Li Song S
Nature nanotechnology 20221124 2
Activation of scramblases is one of the mechanisms that regulates the exposure of phosphatidylserine to the cell surface, a process that plays an important role in tumour immunosuppression. Here we show that chemotherapeutic agents induce overexpression of Xkr8, a scramblase activated during apoptosis, at the transcriptional level in cancer cells, both in vitro and in vivo. Based on this finding, we developed a nanocarrier for co-delivery of Xkr8 short interfering RNA and the FuOXP prodrug to tu ...[more]