Characteristics of fecal microbiota in different constipation subtypes and association with colon physiology, lifestyle factors, and psychological status.

ABSTRACT:

Background

Patients with chronic constipation (CC) show altered gut microbial composition.

Objectives

To compare the fecal microbiota with different constipation subtypes and to identify potential influencing factors.

Design

This is a prospective cohort study.

Methods

The stool samples of 53 individuals with CC and 31 healthy individuals were analyzed using 16S rRNA sequencing. The associations between microbiota composition and colorectal physiology, lifestyle factors, and psychological distress were analyzed.

Results

In all, 31 patients with CC were classified as having slow-transit constipation, and 22 were classified under normal-transit constipation. The relative abundance of Bacteroidaceae was lower, and the relative abundance of Peptostreptococcac

SUBMITTER: Yu T 

PROVIDER: S-EPMC9974631 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature