Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids.

ABSTRACT: The discoveries of human pluripotent stem cells (PSCs) including embryonic stem cells and induced pluripotent stem cells (iPSCs) has led to dramatic advances in our understanding of basic human developmental and cell biology and has also been applied to research aimed at drug discovery and development of disease treatments. Research using human PSCs has been largely dominated by studies using two-dimensional cultures. In the past decade, however, ex vivo tissue "organoids," which have a complex and functional three-dimensional structure similar to human organs, have been created from PSCs and are now being used in various fields. Organoids created from PSCs are composed of multiple cell types and are valuable models with which it is better to reproduce the complex structures of livi

SUBMITTER: Ouchi R 

PROVIDER: S-EPMC9974642 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature