Donation type and the effect of pre-transplant donor specific antibodies - Data from the Swiss Transplant Cohort Study.

ABSTRACT:

Introduction

The type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. Many centers are, therefore, reluctant to perform donor specific antibody (DSA) positive transplantations in the setting of donation after circulatory death (DCD). There are, however, no large studies comparing the impact of pre-transplant DSA stratified on donation type in a cohort with a complete virtual cross-match and long-term follow-up of transplant outcome.

Methods

We investigated the effect of pre-transplant DSA on the risk of rejection, graft loss, and the rate of eGFR decline in 1282 donation after brain death (DBD) transplants and compared it to 130 (DCD) and 803 living donor (LD) transplants.

Results

There was a significant worse outcome

SUBMITTER: de Rougemont O 

PROVIDER: S-EPMC9974644 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature