Low sodium intake ameliorates hypertension and left ventricular hypertrophy in mice with primary aldosteronism.

ABSTRACT: The goal of this paper is to elucidate the effects of sodium restriction on hypertension and left ventricular (LV) hypertrophy in a mouse model with primary aldosteronism (PA). Mice with genetic deletion of TWIK-related acid-sensitive K (TASK)-1 and TASK-3 channels (TASK^-/-) were used as the animal model of PA. Parameters of the LV were assessed using echocardiography and histomorphology analysis. Untargeted metabolomics analysis was conducted to reveal the mechanisms underlying the hypertrophic changes in the TASK^-/- mice. The TASK^-/- adult male mice exhibited the hallmarks of PA, including hypertension, hyperaldosteronism, hypernatremia, hypokalemia, and mild acid-base balance disorders. Two weeks of low sodium intake significantly reduced the 24-h averag

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9974669 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature