Sex modulates the association between inflammation and coronary atherosclerosis among older Ugandan adults with and without HIV.

ABSTRACT:

Objective

Inflammation is key in the pathogenesis of atherosclerotic coronary artery disease (CAD). Distinct sex-specific inflammatory mechanisms may contribute to CAD in sub-Saharan Africa (SSA), where environmental and biological determinants of systemic inflammation may differ from those in high-income settings.

Approach and results

We investigated sex differences in inflammatory markers and CAD in a 2-year prospective cohort of Ugandan adults enriched for cardiometabolic risk factors (RFs) and HIV. Seven plasma biomarkers were quantified at the baseline visit among 125 females and 75 males (50% with HIV) at least 45 years old at enrollment with one or more major cardiovascular RF. In year 2, coronary CT angiography (CCTA) was performed in 82 females and 50 males returnin

SUBMITTER: Shakil SS 

PROVIDER: S-EPMC9974774 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature