Nicotine-Mediated Rescue of α-Synuclein Toxicity Requires Synaptic Vesicle Glycoprotein 2 in Drosophila.

ABSTRACT:

Background

Parkinson's disease (PD) is characterized by α-synuclein aggregation and loss of dopamine neurons. Risk of PD arises due to a combination of genetic and environmental factors, which may interact, termed gene-environment (G×E) interactions. An inverse association between smoking and the risk of PD is well established, and a previous genome-wide G×E interaction study identified genetic variation in the synaptic-vesicle glycoprotein 2C (SV2C) locus as an important mediator of the degree to which smoking is inversely associated with PD.

Objective

We sought to determine the mechanism of the smoking-SV2C interaction in a Drosophila model of PD.

Methods

Flies expressing human α-synuclein in all neurons develop the hallmarks of PD, including motor dysfunction, loss

SUBMITTER: Olsen AL 

PROVIDER: S-EPMC9974823 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature