Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.

ABSTRACT:

Rationale & objective

Clonal hematopoiesis of indeterminate potential (CHIP), defined by the age-related ontogenesis of expanded leukemogenic variants indicative of a genetically distinct clonal leukocyte population, is associated with risk of hematologic malignancy and cardiovascular disease. In experimental models, recapitulation of CHIP promotes kidney interstitial fibrosis with direct tissue infiltration of donor macrophages. We tested the hypothesis that CHIP is associated with kidney function decline in the general population.

Study design

Cohort study.

Setting & participants

12,004 individuals from 3 community-based cohorts in the TOPMed Consortium.

Exposure

CHIP status from whole-genome sequences obtained from DNA extracted from peripheral blood.

Out

SUBMITTER: Kestenbaum B 

PROVIDER: S-EPMC9974853 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature