A panel of blood biomarkers unique to sudden cardiac arrest.

ABSTRACT:

Background

The identification of circulating biomarkers specific for sudden cardiac arrest (SCA) could enhance risk prediction. Of particular interest are biomarkers specific to SCA, independent of coronary artery disease (CAD).

Objective

The purpose of this study was to identify biomarkers of SCA obtained close to the SCA event.

Methods

Twenty cases (survivors of SCA) and 40 age- and sex-matched controls were compared, with a replication analysis of 29 cases matched to 57 controls. A secondary analysis compared 20 SCA cases to 20 controls with CAD. Blood samples were obtained from SCA survivors at a median of 11 months after the SCA event. Proteins were analyzed on a mass spectrometer using data-independent acquisition; a subset of cytokines were analyzed using immun

SUBMITTER: Norby FL 

PROVIDER: S-EPMC9974970 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature