Safety evaluation of axicabtagene ciloleucel for relapsed or refractory large B-cell lymphoma.

ABSTRACT:

Introduction

CD19-directed chimeric antigen receptor (CAR) T-cell therapy is a highly effective therapy for patients with relapsed/refractory large B-cell lymphoma (LBCL) and three CD19 CAR T-cell products (axicabtagene ciloleucel, tisagenlecleucel and lisocabtagene maraleucel) are currently approved for this indication. Despite the clinical benefit of CD19 directed CAR T-cell therapy, this treatment is associated with significant morbidity from treatment-emergent toxicities.

Areas covered

This Review discusses the safety considerations of axicabtagene ciloleucel in patients with LBCL. This includes discussion of the frequently observed immune-mediated toxicities of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. Additionally, we review

SUBMITTER: Nath K 

PROVIDER: S-EPMC9975047 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature