Novel biomarkers for neoplastic progression from ulcerative colitis to colorectal cancer: a systems biology approach.

ABSTRACT: In recent studies, the void of evaluation and in-depth understanding of unknown clinically relevant potential molecular biomarkers involved in colorectal cancer (CRC) from the inflammatory stage of ulcerative colitis (UC) to CRC metastasis, which can be suitable therapeutic targets, is deeply felt. The regulation and interaction among different cancer-promoting molecules, including messenger RNAs (mRNAs) and micro RNAs (miRNAs) in CRC and its progression, were the aim we pursued in this study. Using microarray data, we investigated the differential expression for five datasets, including mRNA and microRNA samples related to UC, tumor/normal. Then, using robust data analysis, separate lists of differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRNAs) were identifi

SUBMITTER: Shahnazari M 

PROVIDER: S-EPMC9975073 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature